MARC, A NOVEL MODULAR CHIMERIC ANTIGEN RECEPTOR, IMPROVES T CELL-BASED CANCER IMMUNOTHERAPIES BY PREVENTING EARLY T CELL EXHAUSTION AND ENHANCING PERSISTENCE

Background Chimeric antigen receptor T cell (CAR-T)-based immunotherapies have reshaped the therapeutic landscape of cancer treatment, in particular for patients afflicted with leukemia.However, defects in CAR behaviors and clinical complications have hindered their widespread application across diverse cancer types.Chief among these defects is hig

Chromosome numbers of 46 specimens of grasses, involving 24 taxa from South Africa and Australia, have been determined during the present study.For the first time chromosome numbers are given for Eragrostis sarmentosa (Thunb.) Trin.(n = 20).Panicum aequinerve Nees (n = COMB 18), Digitaria argyrograpta (Nees) Stapf (n = 9) and D.maitlandii Stapf & C

Neurocysticercosis, caused by the invasion of the central nervous system (CNS) by Taenia solium larvae, poses a significant global health burden.Despite its prevalence and severe neurological consequences, understanding of the molecular and signalling pathways facilitating parasite dissemination and CNS invasion is limited.The lack of comprehensive

Previous research has found that people consult closeness or proximity cues when they evaluate the plausibility or likelihood of a counterfactual alternative to reality.In this paper we asked whether the plausibility of counterfactuals extends to dynamic proximity cues that signal a sense of propensity or acceleration in the lead-up to an outcome.S

Summary: Immunotherapy targeting tumor-associated macrophages (TAMs) is a promising approach to treating cancer.However, the limited drug targets and ambiguous mechanisms impede the development of clinical immunotherapy strategies.To elucidate the underlying processes involved in mononuclear phagocyte (MNP) infiltration and phenotypic changes in Se